679 Pharmacological validation of a mouse model of atopic dermatitis induced by topical calcipotriol
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چکیده
منابع مشابه
P22 – Set-up and validation of a mouse model for food-allergy induced atopic dermatitis
Atopic dermatitis (AD) is a complex disorder characterized by flares of red and itchy skin. Infants with AD often also suffer from food allergy. Both ingestion of and skin contact with the antigen can exacerbate the AD. The affected skin is characterized by oedema formation and shows typical Th2 responses by increased levels of IL-4 and IL-13, but not IFN-g. Furthermore, there is an influx of e...
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Topical tacrolimus as treatment of atopic dermatitis
Atopic dermatitis (AD) is a common, chronic, relapsing, severely pruritic, eczematous skin disease. The mainstays of treatment for AD are topical tacrolimus and topical steroids. Tacrolimus, a calcineurin inhibitor, not only complements existing treatment options but also overcomes some of the drawbacks of topical steroid therapy when given topically and thus meets the long-term needs of patien...
متن کاملAtopic dermatitis: tacrolimus vs. topical corticosteroid use
Atopic dermatitis (AD), the dermatological manifestation of the atopic diathesis, has a variety of clinical presentations. It is a chronic and relapsing inflammatory disorder, requiring a multifaceted treatment approach. Topical corticosteroids are the backbone of therapy. However, concerns over adverse drug reactions associated with their long-term application limit their use. Tacrolimus, on t...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.755